Protein Modification Reagents
eMolecules 198227-38-2 | t-Boc-N-amido-PEG15-amine | Broadpharm | MFCD28385469 | 821.012 | C37H76N2O17 | 95.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 296213670
t-Boc-N-amido-PEG15-amine | Broadpharm | 198227-38-2 | MFCD28385469 | 821.012 | C37H76N2O17 | 95.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN | 1g | 296213670
Cayman Chemical DPPE-MPEG 2000 25mg
A PEGylated form of DPPE; has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention
Medchemexpress LLC 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-Pentadecaoxahexatetracontan-46-amine | 2745717-94-4 | 99.9% | 691.85 | 50 MG
The m-PEG15-amine is a chemical compound with the molecular formula C31H65NO15 and a molecular weight of 691.85. It is provided as a colorless to light yellow oil with a purity of 99.91%. This product is intended for use as a laboratory chemical and in the manufacture of substances. It is classified as hazardous, causing acute oral toxicity, skin and serious eye irritation, and potential respiratory tract irritation.
- Consistent with structure based on ¹H NMR Spectrum and LCMS
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules. PROTACs, composed of two ligands linked together, target an E3 ubiquitin ligase and a specific protein, thereby utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features Alkyne group for CuAAc
- Enables selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC t-Boc-N-amido-PEG5-acetic acid | 890152-41-7 | MFCD31656900 | 98.0% | 395.45 | C17H33NO9 | 1 G
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected PEG-based linker used for assembling PROTACs and other bioconjugates. It provides a flexible, hydrophilic spacer with a terminal acetic acid and a Boc-protected amine, enabling standard coupling and selective deprotection steps during synthesis.
- Provides a five-unit polyethylene glycol spacer for flexible linkage.
- Contains a terminal acetic acid for straightforward conjugation chemistry.
- Features a Boc-protected amine to allow selective deprotection and functionalization.
- Suitable for synthesis of heterobifunctional degraders and bioconjugates.
- Available in multiple pack sizes for research-scale synthesis.
Medchemexpress LLC Rhodamine B PEG2-NH2 | 95.3% | 566.13 | 50 MG
Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG4-methyltetrazine | 1962919-31-8 | 95.3% | 674.81 g·mol⁻¹ | C31H46N8O7S | 10 MG
Biotin-PEG4-MeTz is a biotinylated click-chemistry reagent containing a terminal methyltetrazine that reacts rapidly with trans-cyclooctene via inverse electron-demand Diels-Alder (iEDDA) chemistry. Supplied as a solid, it is intended for preparation of biotinylated conjugates and labeling applications in chemical biology and bioconjugation workflows.
- Contains a terminal methyltetrazine for rapid iEDDA reactions.
- Includes a PEG4 spacer to improve solubility and reduce steric hindrance.
- Facilitates preparation of biotinylated conjugates and biomolecule labeling.
- Purple to purplish red solid; high purity (~95.3%).
- Soluble in DMSO at about 250 mg/mL; ultrasonication recommended.
- Store sealed at -20 °C away from moisture and light; in solution store at -80 °C for long term.
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 25 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker. It is used in the synthesis of Proteolysis-targeting chimeras (PROTACs), which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Pomalidomide-PEG3-azide | 2267306-15-8 | MFCD32198606 | 98.9% | 488.45 | C21H24N6O8 | 5 MG
Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines a pomalidomide-derived cereblon ligand with a three-unit polyethylene glycol linker terminated in an azide. It is intended for use in targeted protein degradation workflows and for click-chemistry functionalization to attach pomalidomide-based ligands to alkyne- or strained-alkyne-containing molecules.
- Facilitates PROTAC construction via CRBN-mediated recruitment of E3 ligase.
- Azide terminus enables copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- PEG3 linker provides flexible spacing between ligand and cargo.
- High reported purity (≈98.9%) supports analytical and synthetic applications.
- Soluble in DMSO at high concentration; store under inert atmosphere at -20°C to preserve stability.
Medchemexpress LLC Pomalidomide-PEG4-azide | 2271036-47-4 | 99.8% | C23H30N6O8 | 250 MG
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a linker used in PROTAC technology. This click chemistry reagent contains an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. Pomalidomide-PEG4-azide is intended for research use only.
- Incorporates a Pomalidomide-based cereblon ligand
- Utilizes a linker used in PROTAC technology
- Features an Azide group for click chemistry reactions
- Enables copper-catalyzed azide-alkyne cycloaddition
- Facilitates strain-promoted alkyne-azide cycloaddition
- Intended for research use only
Medchemexpress LLC Biotin-PEG6-Mal | 1808990-66-0 | MFCD28015769 | 99.0% | C31H51N5O11S | 25 MG
Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand with a target protein ligand.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-Mal-N-bis(PEG4-NHS ester) | 2112738-60-8 | ≥95.0% | C37H54N4O19 | 100 MG
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It is designed for research applications, leveraging the intracellular ubiquitin-proteasome system for targeted protein degradation.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Connects ligands for E3 ubiquitin ligase and target proteins
- Employs ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | C40H81N3O20 | 25 MG
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker for PROTAC synthesis.
- Click chemistry reagent containing an Azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
Medchemexpress LLC Biotin-PEG11-Mal | 1646619-56-8 | 96.5% | C41H71N5O16S | 50 MG
Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Utilizes E3 ubiquitin ligase and target protein ligands
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Hydroxy-PEG4-CH2COOH | 70678-95-4 | ≥97.0% | C10H20O7 | 500 MG
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins